DKWSLLL, a Versatile DXXXLL-Type Signal with Distinct Roles in the Cu+-Regulated Trafficking of ATP7B
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چکیده
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Modification by Lys63-linked ubiquitin (UbK63) chains is the second most abundant form of ubiquitylation. In addition to their role in DNA repair or kinase activation, UbK63 chains interfere with multiple steps of intracellular trafficking. UbK63 chains decorate many plasma membrane proteins, providing a signal that is often, but not always, required for their internalization. In yeast, plants,...
متن کاملBasolateral sorting and transcytosis define the Cu+-regulated translocation of ATP7B to the bile canaliculus.
The Cu(+) pump ATP7B plays an irreplaceable role in the elimination of excess Cu(+) by the hepatocyte into the bile. The trafficking and site of action of ATP7B are subjects of controversy. One current proposal is that an increase in intracellular Cu(+) results in the translocation of ATP7B to the lysosomes and excretion of excess Cu(+) through lysosomal-mediated exocytosis at the bile canalicu...
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ژورنال
عنوان ژورنال: Traffic
سال: 2014
ISSN: 1398-9219
DOI: 10.1111/tra.12176